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Network Biology of Genes Involved in Cancer: Basal Cell Carcinoma, Squamous Cell Carcinoma, Throat Cancer, Thyroid Cancer and Oral CancerNetwork Biology of Genes Involved in Cancer: Basal Cell Carcinoma, Squamous Cell Carcinoma, Throat Cancer, Thyroid Cancer and Oral Cancer

Author(s): Ashish Kumar Thakur, School of Life Sciences, SIILAS Campus, Jaipur National University, Jaipur-203017; Jaisri Jagannathan, School of Life Sciences, SIILAS Campus, Jaipur National University, Jaipur-203017

Keywords:Network Biology, Hubs, Genemania, Cancers

Abstract : Network biology and data mining processes are helpful enough to provide detailed information about the genes and their networks which paves the way for drug designing. Here, in this study the genes implicated in cancer such as Basal cell carcinoma (BCC), Squamous cell carcinoma (SCC), Throat cancer, Thyroid cancer and Oral cancer are retrieved and the network comprising co-expression, co-localization, genetic interactions, physical interactions, pathways, predicted, shared-protein domain is generated. Network properties and hubs for the predicted network were identified. The hubs predicted for example, smoothened, fizzled class receptor (SMO) in Basal cell carcinoma can be considered as potential drug targets for drug designing.

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